Subjects recruited at nine different centers throughout Europe and South America were included in the analysis. GST genotyping data were available for 122 lung cancer cases and 123 controls. , we have examined associations between GSTM1 genotypes, cruciferous vegetable intake and lung cancer risk.

Using data from a multicenter study of lung cancer among nonsmokers (4) This could represent an important example of a gene-environment interaction in human carcinogenesis. Among individuals who are genetically deficient with respect to the GST enzymes, elimination of isothiocyanates is likely to be less rapid, which may enhance their chemopreventive effect. GST-catalyzed conjugation of glutathione with isothiocyanates promotes the elimination of these compounds (3) Isothiocyanates, which have been shown to inhibit tumorigenesis in animal models, are non-nutrient compounds found in cruciferous vegetables. Have recently shown a protective effect of a high serum isothiocyanate level for lung cancer risk, primarily among GSTM1-null individuals, in a Chinese population. This protective effect was greater in individuals who were null for both GSTM1 2Īnd GSTT1 genotypes compared with subjects who had positive alleles for both genes, but there appeared to be no interaction between dietary isothiocyanate intake and GSTM1 genotype alone. Have recently described a protective effect of dietary isothiocyanate intake for lung cancer risk in a United States population among current, but not among former, smokers.

Risk pc 2000